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Glutamates and Anti-depressants

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Anonymous
Posted on Saturday, May 07, 2005 - 12:20 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

I found this interesting article on research regarding anti-depressants. It is being done through the NIMH. They are looking into glutamate blockers as a new type of anti-D. I haven't been able to use anti-D's in the past. They made me jittery and caused a variety of negative side effects. Besides - they just didn't help!

For the complete article:
http://www.gulfnews.com/Articles/Features2.asp?ArticleID=136033

Researchers delve deeper into depression's chemistry

Another possible target is glutamate, a neurotransmitter that sends excitatory messages, telling the brain to pay attention. Too much glutamate overstimulates and damages nerve cells, and researchers suspect that this chemical system goes awry in depression.

In animal tests, lowering glutamate levels improves depressive behaviour and has recently been shown to stimulate neurogenesis.

Glutamate blockers

Manji and his NIMH colleagues are interested in two glutamate blockers used for other ailments. They are memantine, an Alzheimer's drug, and riluzole, which is used for Lou Gehrig's disease.

In a small human trial, riluzole worked "remarkably well" for some depression patients, Manji said. "We're thinking that there may be a subpopulation in whom this may really help," he said.

Scientists are increasingly recognising that, as the riluzole results suggest, depression is probably not a single disorder, but rather a collection of related subtypes. All depressives feel unhappy and hopeless,

but some are agitated and sleepless,

and others hardly move and can hardly stay awake.
Jerry Story
Posted on Saturday, May 07, 2005 - 1:33 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Two courses of action:
1. Stay off glutamate.
2. Take glutamate blockers.

The first:
-- is better for the patient.
-- is "unscientific".

The second:
-- is more lucrative for the doctor.
-- is a "breakthru in medicine".
Anonymous
Posted on Monday, March 06, 2006 - 1:04 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

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Anonymous
Posted on Friday, July 07, 2006 - 11:11 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

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