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Alzheimer's and calcium

Battling the MSG Myth » Sharing Media Reports and Letters Related to the Issue » Alzheimer's and calcium « Previous Next »

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Carol H
Posted on Friday, July 30, 2004 - 12:32 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

The latest news on Alzheimer's again bolsters our case. There is apparently a link between Alzheimers and excess calcium. http://www.thestar.com/NASApp/cs/ContentServer?pagename=thestar/Layout/Article_Type1&c=Article&cid=1091139010901&call_pageid=968332188492&col=968793972154
Remember - Glutamate is a calcium channel OPENER. Perhaps calcium channel blockers - like the ones currently used to treat heart disease, may have a new use.
Anonymous
Posted on Monday, March 06, 2006 - 2:41 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

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Anonymous
Posted on Friday, July 07, 2006 - 4:41 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

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Hoofbears in heav'n
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Posted on Friday, May 06, 2016 - 11:03 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Does any one know if any of this relates to calcium deposits in the muscles?
I clicked the link, but it goes to a site with many articles. How do i find the one about calcium and Alzheimer's?
I am up late because i took a risk and had on organic box mix pudding before bed. I felt just fine after, but im unable to sleep, so i am on here looking for more answers.
Tom Fernstrom
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Posted on Saturday, May 07, 2016 - 8:16 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Hoofbeats,

To truly understand the effects of MSG, you must observe what happens at the cellular level. Dr. Russell Blaylock explains this very well in his book
"Excitotoxins: The Taste That Kills"

As Carol of (http://msgtruth.org/) alludes to above, MSG acts on the cell as a calcium channel Opener which means the cell mitochondria is being flooded with calcium which excites the cell to the point of severe damage or in some cases death - thus the term "Excitotoxins". Calcium channel blockers are used to lessen cell damage by blocking the cell ability to uptake calcium. You can see the most dramatic use of this drug when stroke patients are treated with the drug. It prevents calcium damage that occurs when blood flow to the brain cells is restricted. Doctors still need to correct the blood flow problem, but keeping the cells alive while this is done helps the patient recover when blood flow is returned.

Another method of protecting the cells from this damage is to supplement supplies of ATP - the cells source of energy which allows it to withstand the onslaught of Calcium from MSG.

CoQ10, Magnesium, Omega-3 fat and Taurine supplementation will help keep the body able to survive the MSG onslaught by increasing the amount of ATP available to the cells.

Here is an article where Blaylock talks about sudden death syndrome: https://dl.dropboxusercontent.com/u/28675161/Russell_Blaylock_M.D./Articles/Entries/2009/4/13_Sudden_Cardiac_Death_and_Food_Excitotoxin_Additives.html
Lee
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Posted on Wednesday, May 11, 2016 - 2:23 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Very interesting, thanks again Tom. Last year my family practitioner doctor gave me a prescription for a very low dose calcium channel blocker to take next time I get an acute reaction (heart racing/PSVT) if I can't get it settled down with Advil and lots of water. I didn't understand the science at the time.
Tom Fernstrom
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Posted on Saturday, May 14, 2016 - 7:05 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Lee,

My MSG reaction is Atrial Fibrillation. I would carry 300 mg of CoQ10 with me at all times. That seemed to work well for me if I ingested MSG - within a half hour the A-Fib would subside after taking the CoQ10. :-)
Roy Piwovar
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Posted on Saturday, May 14, 2016 - 9:08 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Good move, Tom! http://www.ncbi.nlm.nih.gov/pubmed/24458150
Tom Fernstrom
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Posted on Tuesday, May 17, 2016 - 7:23 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Roy,

Interesting article. My mother eventually went blind from glaucoma and was having A-Fib reactions around the time I became aware of the MSG cause of my A-Fib. She had a catheter ablation procedure to block the errant heart signals, but since she refused to stop eating MSG on my suggestion, her A-Fib returned and her glaucoma worsened. I was diagnosed with glaucoma like pressures back then too, but since I succeeded in avoiding MSG, my pressures have stabilized and I have not yet needed medication. That was 18 years ago. :-)
Roy Piwovar
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Posted on Tuesday, May 17, 2016 - 4:08 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Tom,

Good for you, but sorry about what happened to your mother. Perhaps if she had adopted your strategy she may have been able to slow down or lessen the damage. All we can do is try.
Pat
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Posted on Wednesday, May 18, 2016 - 1:43 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Roy & Tom,
Assuming avoidance of MSG, if one get an attack anyway, a few Co Q10 questions:

Taken after &/or before?
# milligrams?
Ubiquinol?

Thanks!
Tom Fernstrom
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Posted on Thursday, May 19, 2016 - 10:17 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Pat,

I take 300MG of CoQ10 daily and carry 300MG with me to take if I get an A-Fib attack. The gelcaps are from Sam's Club Member's Mark Brand.
Pat
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Posted on Sunday, May 22, 2016 - 8:10 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Thanks Tom!
Deb A.
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Posted on Thursday, May 26, 2016 - 6:39 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

The gelatin doesn't bother you, Tom? I would love to find CoQ10 without gelatin...hard to find. I have bought powdered CoQ10 from Beyondacentury.com. I mix a little with olive oil and take from spoon. Not sure it bypasses the stomach acids, though.
Deb A.
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Posted on Thursday, May 26, 2016 - 6:42 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Roy, found that article on glaucoma very interesting. I have borderline glaucoma, but have kept my pressure number low enough since avoiding MSG that I do not need meds.
Tom Fernstrom
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Posted on Thursday, May 26, 2016 - 8:24 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Deb A.,

You present a very good question and I explored the dosage recommendations with a few renowned CoQ10 scientists back in 2000. Below is a correspondence I was able to salvage from your discussion board before some was lost back then.

The bottom line after it seemed as my correspondence was falling on deaf ears, was that I settled on the higher 300mg CoQ10 dosage. In that dosage, it seemed to offset the adverse effects of the soy oil that the gel cap contained and is presumed to be hydrolyzed and contain free glutamate. You are also correct to be concerned with the digestive actions on the powdered CoQ10 as the gel caps are designed to be able to pass through the stomach and get to the small intestine where it is better absorbed for delivery to the bloodstream.

I've posted some links at the end below of more current COQ10 info.

@@@@@@@@@@@@@@@@@@@@

Dr. Peter Langsjoen,

If you will forgive my intrusion, I would like to comment on and seek some information regarding your Introduction to Coenzyme Q10.

"Karl Folkers takes the position that the dominant source of CoQ10 in man is biosynthesis. This complex, 17 step process, requiring at least seven vitamins (vitamin B2 - riboflavin, vitamin B3 - niacinamide, vitamin B6, folic acid, vitamin B12, vitamin C, and pantothenic acid) and several trace elements, is, by its nature, highly vulnerable. Karl Folkers argues that suboptimal nutrient intake in man is almost universal and that there is subsequent secondary impairment in CoQ10 biosynthesis. This would mean that average or "normal" levels of CoQ10 are really suboptimal and the very low levels observed in advanced disease states represent only the tip of a deficiency "ice berg". "

"All metabolically active tissues are highly sensitive to a deficiency of CoQ10. CoQ10's function as a free radical scavenger only adds to the protean manifestations of CoQ10 deficiency."

Is it possible that normal levels of CoQ10 are being produced, but are being compromised (used up) by some other substance that is robbing the cells of energy? This substance (I will call Excitotoxins) could be forcing the cells to use excessive energy first to eliminate free glutamate and then to counter the free radicals created in damaged cells? In the cases of added Monosodium Glutamate and Aspartame to food products either intentionally or as a byproduct, the majority of the industrialized nations' population is affected.

"Increased body consumption of CoQ10 is the presumed cause of low blood CoQ10 levels seen in excessive exertion, hypermetabolism, and acute shock states. " "CoQ10 is particularly high in organ meats such as heart, liver and kidney, as well as beef, soy oil, sardines, mackerel, and peanuts"

The current dietary recommendations advise against fat consumption. Many food products produced to capitalize on this advice replace fat and its savory flavor with MSG (free glutamate) producing flavor & texture additives. At the same time people are advised to refrain from eating the very foods where CoQ10 is naturally present.

"In 1958, Professor Karl Folkers and coworkers at Merck, Inc., determined the precise chemical structure of CoQ10: 2,3 dimethoxy-5 methyl-6 decaprenyl benzoquinone (Fig. 1), synthesized it, and were the first to produce it by fermentation. "

We MSG reaction sufferers have been told that it is the fermentation process used to create MSG and other products that causes excessive free glutamate in our foods. Ancient Asian cultures used to boil seaweed to create the "natural" flavor-enhancing product that we commonly call MSG today. But today's fermentation process uses a variety of other foodstuffs as a base and is far from chemically similar to the original. Thus as we ingest these free glutamate laden foodstuffs we end up robbing our body's cell structures of the very nutrients we are trying to consume. Are we sure the current CoQ10 manufacturing process is not also creating free glutamate? Could this be why it is seen that higher doses are more affective?

"By the mid-1970's, the Japanese perfected the industrial technology to produce pure CoQ10 in quantities sufficient for larger clinical trials. All CoQ10 available today in the United States is manufactured in Japan and is distributed by a number of companies who place the CoQ10 either in pressed tablets, powder-filled capsules, or oil-based gelcaps. CoQ10 is fat-soluble and absorption is significantly improved when it is chewed with a fat-containing food."

Is it a coincidence that the largest manufacturers of MSG and CoQ10 are the Japanese?

Thank you for allowing me to comment.

@@@@@@@@@@@@@@@@@@@@@@@@

Dr Karl Folkers

http://beyondprescriptions.org/tag/dr-karl-folkers/#sthash.TVyBBS7m.dpbs

Dr. Peter H. Langsjoen
https://www.youtube.com/watch?v=8gOZqJkQVtU
Professor Gian Paolo Littarru
http://icqaproject.org/
Tom Fernstrom
Unregistered guest
Posted on Thursday, May 26, 2016 - 10:45 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Deb A.,

Just for the heck of it, I thought I would write to Dr. Langsjoen again:

@@@@@@@@@@@@@@@@@@@@
Dr. Langsjoen,

Please excuse my intrusion.

I tried contacting you back in July of 2000 after contacting Professor Gian Paolo Littarru with my questions and observations about CoQ10. He referred me to you. I have pasted the email I sent you last below and it was your wife, Alena, who responded to my email back then. I have since lost that response, but recall that she mentioned that you too were possibly adversely affected by MSG.

I just recently watched your 2007 discussion on CoQ10 on "youtube" at:
https://www.youtube.com/watch?v=8gOZqJkQVtU

I'm sure your research since then has shown more linkages of CoQ10 supplementation to improvements in cardiac health and I would be interested in any further information on the use of statins and subsequent depletion of CoQ10 serum levels.

But I'm most interested in exploring the link between the ingestion of "Excitotoxins" in our society and their adverse affects on cellular mitochondria. Dr. Russell Blaylock in his book "Excitotoxins: The Taste that Kills" explains at great length the affects of MSG and Aspartame consumption on the body's ability to cope under the great stress these Excitotoxins present. Excitotoxins rob the cell of energy by opening the mitochondria's calcium channels.

Our current society ingests these excitotoxins in greater and greater levels each day because they are "hidden" in our processed foods as hydrolyzed vegetable proteins. My contention is that no study of CoQ10's beneficial effects can ignore the study patient's diet. If that patient does not restrict the ingestion of Excitotoxin laden foods, the CoQ10 serum levels will be skewed by the fact that much of the CoQ10 prescribed is being used by the cells for energy to fight off the Excitotoxin damage and depletion of ATP.

One other interesting observation is that the delivery mechanism of many CoQ10 supplements includes the encapsulation of the material in a gel pill also containing soy oil for better CoQ10 absorption. If you consider that soy oil production requires hydrolyzing of the oil before refining, the gel capsule design is adding free glutamate and thus limiting the CoQ10 benefit.

As you quoted Robertson Davies, "The eyes see only what the mind is prepared to comprehend."

Thanks for your attention.

Sincerely,

Tom Fernstrom

:-)
Roy Piwovar
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Posted on Thursday, May 26, 2016 - 4:25 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Deb A., you may want to check out the vegetarian versions, such as: http://www.vitacost.com/vitacost-coq10-100-mg-120-vegetarian-capsules-3

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