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Stress reduces glutamate receptors

Battling the MSG Myth » Sharing Scientific Information » Stress reduces glutamate receptors « Previous Next »

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Jennifer
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Posted on Tuesday, March 13, 2012 - 8:24 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

http://www.ivanhoe.com/channels/p_channelstory.cfm?storyid=29074

Can anyone access the actual study? I'm curious about two things:

Were the glutamate receptors destroyed by excitotoxic reactions?

Were glutamate blockers used to prevent receptor loss?

Jennifer
Roy Piwovar
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Posted on Tuesday, March 13, 2012 - 12:39 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Jennifer, I think you're looking for this:

http://www.acsu.buffalo.edu/~zhenyan/stress-neuron%20paper.pdf
Jennifer
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Posted on Tuesday, March 13, 2012 - 8:02 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Thank you, Roy.

Quickly scanning it, they used RU486 to prevent receptor loss. A powerful glutamate blocker. That doesn't prove my first question, but I sure suspect it's so. Will read it in depth later.

Jennifer
Jennifer
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Posted on Saturday, March 17, 2012 - 8:54 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Hmmm...I was thinking of MK801. In the article it stated : "Systemic injections of the GR antagonist RU486 blocked the
decreasing effect of repeated restraint stress on AMPAR-EPSC(Figure 2G,....."

So I wonder if RU486 has other properties besides the commonly known use...

Jennifer
Zoomer
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Posted on Sunday, March 18, 2012 - 12:59 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

The most interesting theory about this biochemistry has been developed by professor Martin Pall. He offers a comprehensive model for the dysfunctional molecular pathways for a range of problems, including MSG sensitivity.

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