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Leptin, GABA & Glutamate

Battling the MSG Myth » Sharing Scientific Information » Leptin, GABA & Glutamate « Previous Next »

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Unregistered guest
Posted on Thursday, July 14, 2011 - 8:53 am:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Interesting connection. One thought I had, is that simply eating too much can make you more susceptible to MSG because the excessive leptin interferes with GABA. I wonder what the implications would be for a state of leptin resistance?

Food for thought.
(Pardon the pun).

Modulation of Inhibitory Output Is Key Function of Antiobesity Hormone

"In the current study, Dr. Lowell and colleagues took a new approach for identifying these "unidentified" body weight-regulating neurons and investigated whether leptin's effects are mediated primarily by excitatory (glutamate) or inhibitory (GABA) neurons. "Remarkably, we found that leptin's antiobesity effects are mediated predominantly by GABA neurons and that glutamate neurons play only a small role," says Dr. Linh Vong, a first author on the study. Importantly, the GABA neurons are "upstream" of the POMC neurons and, in response to leptin, the GABA neurons are less active. Conversely, a reduction in leptin levels, such as occurs with fasting, increases the activity of these GABA neurons."
Deb A.
Unregistered guest
Posted on Wednesday, July 20, 2011 - 8:49 pm:   Delete PostPrint Post   Ban Poster IP (Moderator/Admin only)

Interesting, Jennifer. You made a good suggestion. Since MSG can interfere with GABA production (from other studies), it makes sense.

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