Posted From: 220.127.116.11
|Posted on Wednesday, September 12, 2007 - 12:28 pm: || |
I don't really know what to make of this, but thought I'd share....
Posted From: 18.104.22.168
|Posted on Wednesday, September 12, 2007 - 2:08 pm: || |
I was shocked to read your post, since I just posted a question about N-Acetyl Cysteine a minute ago. How does it "impact" the amino acid glutamate? Maybe this form of cysteine counteracts the effects of the l-cysteine and glutamate? I read that glutamate makes people have more addictive type behavior, such as mentioned in this link. It influences impulsive behavior for the worse according to something I read that Dr. Blaylock wrote.
|Posted on Wednesday, September 12, 2007 - 10:41 pm: || |
This is very interesting. Is N-Acetyl Cysteine a type of "glutamate blocker"? That would be awesome if it is. I just started taking it at my doctor's suggestion.
I don't mind experimenting on myself.
|Posted on Thursday, September 13, 2007 - 1:17 am: || |
I haven't heard that about N-Acetyl Cysteine, but Blaylock has written about another chemical, phosphatidylserine:
"It is known that phosphatidylserine is a natural glutamate blocker. It has also been shown to improve cell membrane stability and fluidity. As we age our cell membranes become stiffer, interfering with their normal operation in a multitude of functions such as electrolyte exchange gradients, receptor function, and impulse generation. Phosphatidylserine appears to restore a more youthful composition to these vital membranes. This intriguing compound has also shown promise in Alzheimer's patients. Most improved on several measures of cognitive functions and the result appeared to be most dramatic in those having earlier stages of the disease."
|Posted on Thursday, September 13, 2007 - 11:31 am: || |
Phosphatidylserine is naturally found in foods.
"Phosphatidylserine is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes. In apoptosis, phosphatidylserine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. Phosphatidylserine (PS) has been used to slow cognitive decline in early-onset Alzheimer's disease.  The substance is sold as a dietary supplement to people who believe they can benefit from an increased intake.
The dietary supplement was originally processed from cow brains. Prion disease scares in the 1990s outlawed this process, and soon a soy-based alternative was developed. PS sold now is made from plants instead of animals."
|Posted on Thursday, September 13, 2007 - 6:48 pm: || |
Don't do it. Cysteine and glutamate compete for uptake that is why they look at it as a glutamate blocker, but cysteine can also be excitotoxic according to research I read going back many years. Better to take taurine instead. That's what the cysteine was going to be used for.
|Posted on Friday, September 14, 2007 - 1:37 pm: || |
Carol, what is the difference between l- cysteine, which we know to be an excitotoxin, and N-Acetyl Cysteine?
|Posted on Sunday, September 16, 2007 - 5:20 am: || |
Remember that NAC is not the same as the excitoxin cystein. Life Extension Foundation recommends NAC for its
anti-oxidant and other properties.
They also say that vitamin C should be taken together with NAC (forgot shy).
|Posted on Sunday, September 16, 2007 - 11:59 am: || |
I have not studied this extensively and do not know too much about it, but it is always best to gather information from sources that don't have a monetary gain from promoting a product. Most of what I've found deals with treatment for a disease or condition.
Deficiencies of NAC have not been defined and may not exist. Deficiencies of the related amino acidcysteine have been reported in HIV-infected patients.
Healthy people do not need to supplement NAC. Optimal levels of supplementation remain unknown, though much of the research uses 250-1,500 mg per day.
Speaking to BBC News Online, he added: "This study is encouraging but we need rigorous clinical trials in humans."
The findings were presented at the American College of Neuropsychopharmacology annual meeting in San Juan, Puerto Rico.
|Posted on Sunday, September 16, 2007 - 10:58 pm: || |
I have seen some references of Dr. Blaylock recommending NAC for detoxing from aspartame in the diet. I don't consider myself a huge use of aspartame, but I did get some in the form of sugar-free gums, medicines, and "light" yogurt, etc. So I feel pretty comfortable about taking NAC. I do suppose it's best to get your nutrients from eating whole foods. I'll try this maybe until the bottle is gone, and see how I do. So far no problems to report, though I'm not as sensitive as some.
|Posted on Saturday, September 29, 2007 - 5:10 am: || |
Becky, My Naturopath just recommended that I take NAC also. I haven't started on it yet, just got it yesterday. I was wondering (if you're still reading this board!) how you're doing on it and if it has caused any problems or how is has helped. Also, how much are you taking? Thanks!
|Posted on Saturday, September 29, 2007 - 10:32 am: || |
Well, I took the one bottle, and I think I did okay. I did have some problems, but it was probably from eating in restaurants too often. I haven't bought any more. My ND didn't really say how long to take it for. I don't want to take it for the rest of my life! So I guess I'm going to stop for now. I was taking it because I have had chronic sinusitis, and it's supposed to thin the secretions. I've been a lot better lately - haven't been sick - so that's why I'm going to stop.
|Posted on Sunday, September 30, 2007 - 6:33 am: || |
Mercola just posted this about NAC at
"Researchers at the University of Virginia Health System have discovered troubling side effects of N-acetylcysteine (NAC), a common antioxidant used in nutritional and bodybuilding supplements.
NAC can form a red blood cell-derived molecule called nitrosothiol that fools your body into thinking there’s an oxygen shortage, which can lead to pulmonary arterial hypertension (PAH).
PAH is a serious condition, where the arteries in the lungs narrow, increasing the blood pressure in your lungs, causing the right side of your heart to swell.
Lead researcher Dr. Ben Gaston, noted that this is an entirely new understanding of how oxygen is sensed by the body. As it turns out, your body responds to the nitrosothiols, which are created when a decreased amount of oxygen is carried by red blood cells -- not to the amount of oxygen dissolved in the blood.
So far, studies have only been performed on mice. The next step is to determine the threshold at which the antioxidant becomes detrimental to heart and lung function in humans. (His original source can be found at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17786245)
Mercola comments further:
N-acetylcysteine (NAC) is an acetylated amino acid and a precursor of glutathione, another potent antioxidant that prevents free radical damage from toxic exposures.
NAC is also a common emergency room treatment for people who have overdosed on acetaminophen (the active ingredient in pain relievers like Tylenol).
Interestingly, NAC is actually used to treat several types of lung disease, and although this animal study connects it with constriction of lung arteries, at least one other study has linked NAC with improved blood flow, stating NAC might increase the biologic effects of nitric oxide by combining with it to form S-nitrosothiol, which is a potent vasodilator. They found that NAC also increases the expression of nitric oxide synthase and may thus improve blood flow as well.
Since I don’t frequently use supplements, I consulted one of my friends, Dr. William LaValley from Austin, Texas, who is an expert in this area and has reviewed the literature thoroughly. He successfully uses supplements as a therapeutic tool in many chronic conditions including cancer.
He felt that PAH may be species specific and possibly won’t happen in humans, and more importantly, the study used much higher doses than are generally used in humans. As mentioned, there are many studies supporting the anti-oxidant benefit of NAC for pulmonary function in cystic fibrosis, post-radiation, and other high oxidant conditions. His conclusion, and I agree, is that a little is probably ok - even good for you. He has used NAC liberally in his therapeutic protocols for nearly 20 years and has not observed any problems with it. However using large quantities is probably not good for you. Long-term high doses are probably not so good for several reasons - including the possibility of PAH.
The study says that the doses are higher than usual in humans - but we know that the supplement manufacturers have been making 500mg NAC caps and selling them by the truckload for years. My biggest concern is the use of NAC by cancer patients who think it is helping - when in fact it may be harmful to them by protecting cancer cells and counteracting what potential benefit they may get from some conventional treatments. It's a thorny issue.
So, if used therapeutically, it should be used in low doses for 'prevention.' High doses should be restricted to disease/stress states that have high likelihood of high reactive oxygen species generation (such as trauma, certain types of infection, malnutrition, and certain types of toxicity).
Dr. LaValley feels that 200-500mg once a day is probably ok in most non-cancer cases. NAC is an important consideration for inclusion, at some reasonable dose, in anti-aging formulas.
However, please remember that the best way to get your antioxidants is to make sure you’re getting them from whole foods, not from supplements, which are often isolated synthetics rather than the readily bioavailable version. What you need is the Goldilock’s equation – not too many and not too few antioxidants – to achieve and maintain optimal health, and it is quite easy to overdose when you take supplements. Fortunately, your body does a phenomenal job of self-regulating many of these levels if you supply it with wholesome, healthy foods and limit your intake of processed foods, which are frequently loaded with artificial chemicals.
Normalizing your insulin and leptin levels is also quite helpful, as elevated insulin and leptin levels cause absolute biochemical havoc in your body and worsen nearly every major part of your physiology. Normalizing your blood sugar will raise your glutathione levels naturally, rather than taking glutathione or precursor supplements.
Glutathione, along with vitamin E, vitamin C and alpha lipoic acid are the basic antioxidants. Some nutritional authorities recommend you take it as a supplement, or take an NAC supplement. There are problems with both. First, the form of glutathione that works best is the reduced form, which is very difficult to absorb orally. Secondly, I advise against using NAC if you still have mercury amalgam fillings because it could interfere with the detoxification of the mercury.
It is much better to get your glutathione through items like alpha lipoic acid that regenerates glutathione. It also has the added ability to generate other antioxidants such as vitamins C and E. The best sources of alpha lipoic acid are red meat and organ meats. Just make sure to stick with grass-fed organic meats, to get the maximum nutrient content and none of the added antibiotics or pesticides.
Glutamine is also a useful nutrient that improves intestinal health and also serves as a direct precursor to glutathione, and some investigators believe it to be the rate-limiting nutrient for glutathione formation. However, in large quantities it can be problematic as Dr. Blaylock outlines in his book “Excitotoxins.”
|Posted on Monday, October 01, 2007 - 6:32 am: || |
Good info. Thanks MEMorris!
|Posted on Monday, October 01, 2007 - 12:50 pm: || |
Thanks! I think I'm going to skip taking it for now. I've taken one capsule each morning the last three mornings. The only thing I noticed and I'm not positive it was from the NAC, is that I got super sleepy. Strange. I decided today after that happened that I wasn't going to take anymore. Now, after reading the above, I don't want it.